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Engineering human mini-bones for the standardized modeling of healthy hematopoiesis, leukemia, and solid tumor metastasis

JOURNAL ARTICLE published 12 October 2022 in Science Translational Medicine

Authors: Ani Grigoryan | Dimitra Zacharaki | Alexander Balhuizen | Christophe RM Côme | Alejandro Garcia Garcia | David Hidalgo Gil | Anne-Katrine Frank | Kristina Aaltonen | Adriana Mañas | Javanshir Esfandyari | Pontus Kjellman | Emelie Englund | Carmen Rodriguez | Wondossen Sime | Ramin Massoumi | Nasim Kalantari | Sujeethkumar Prithiviraj | Yuan Li | Steven J Dupard | Hanna Isaksson | Chris D Madsen | Bo T Porse | Daniel Bexell | Paul E Bourgine

Stem-like CD4 + T cells in perivascular tertiary lymphoid structures sustain autoimmune vasculitis

JOURNAL ARTICLE published 6 September 2023 in Science Translational Medicine

Authors: Yuki Sato | Abhinav Jain | Shozo Ohtsuki | Hirohisa Okuyama | Ines Sturmlechner | Yoshinori Takashima | Kevin-Phu C. Le | Melanie C. Bois | Gerald J. Berry | Kenneth J. Warrington | Jörg J. Goronzy | Cornelia M. Weyand

β2-spectrin (SPTBN1) as a therapeutic target for diet-induced liver disease and preventing cancer development

JOURNAL ARTICLE published 15 December 2021 in Science Translational Medicine

Authors: Shuyun Rao | Xiaochun Yang | Kazufumi Ohshiro | Sobia Zaidi | Zhanhuai Wang | Kirti Shetty | Xiyan Xiang | Md. Imtaiyaz Hassan | Taj Mohammad | Patricia S. Latham | Bao-Ngoc Nguyen | Linda Wong | Herbert Yu | Yousef Al-Abed | Bibhuti Mishra | Michele Vacca | Gareth Guenigault | Michael E. D. Allison | Antonio Vidal-Puig | Jihane N. Benhammou | Marcus Alvarez | Päivi Pajukanta | Joseph R. Pisegna | Lopa Mishra

TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia

JOURNAL ARTICLE published 17 January 2024 in Science Translational Medicine

Authors: Jordan D. Marks | Virginia Estades Ayuso | Yari Carlomagno | Mei Yue | Tiffany W. Todd | Ying Hao | Ziyi Li | Zachary T. McEachin | Anantharaman Shantaraman | Duc M. Duong | Lillian M. Daughrity | Karen Jansen-West | Wei Shao | Anna Calliari | Jesus Gonzalez Bejarano | Michael DeTure | Bailey Rawlinson | Monica Castanedes Casey | Meredith T. Lilley | Megan H. Donahue | Vidhya Maheswari Jawahar | Bradley F. Boeve | Ronald C. Petersen | David S. Knopman | Björn Oskarsson | Neill R. Graff-Radford | Zbigniew K. Wszolek | Dennis W. Dickson | Keith A. Josephs | Yue A. Qi | Nicholas T. Seyfried | Michael E. Ward | Yong-Jie Zhang | Mercedes Prudencio | Leonard Petrucelli | Casey N. Cook

A phase 1-2 trial of sitravatinib and nivolumab in clear cell renal cell carcinoma following progression on antiangiogenic therapy

JOURNAL ARTICLE published 20 April 2022 in Science Translational Medicine

Authors: Pavlos Msaouel | Sangeeta Goswami | Peter F. Thall | Xuemei Wang | Ying Yuan | Eric Jonasch | Jianjun Gao | Matthew T. Campbell | Amishi Yogesh Shah | Paul Gettys Corn | Alda L. Tam | Kamran Ahrar | Priya Rao | Kanishka Sircar | Lorenzo Cohen | Sreyashi Basu | Fei Duan | Sonali Jindal | Yuwei Zhang | Hong Chen | Shalini S. Yadav | Ronald Shazer | Hirak Der-Torossian | James P. Allison | Padmanee Sharma | Nizar M. Tannir

A technology platform to assess multiple cancer agents simultaneously within a patient’s tumor

JOURNAL ARTICLE published 22 April 2015 in Science Translational Medicine

Research funded by NIH (1R01 CA155360,T32 CA080416) | NCI (5R42 CA144104,2R01 CA114567)

Authors: Richard A. Klinghoffer | S. Bahram Bahrami | Beryl A. Hatton | Jason P. Frazier | Alicia Moreno-Gonzalez | Andrew D. Strand | William S. Kerwin | Joseph R. Casalini | Derek J. Thirstrup | Sheng You | Shelli M. Morris | Korashon L. Watts | Mandana Veiseh | Marc O. Grenley | Ilona Tretyak | Joyoti Dey | Michael Carleton | Emily Beirne | Kyle D. Pedro | Sally H. Ditzler | Emily J. Girard | Thomas L. Deckwerth | Jessica A. Bertout | Karri A. Meleo | Ellen H. Filvaroff | Rajesh Chopra | Oliver W. Press | James M. Olson

Tuberculosis Immunopathology: The Neglected Role of Extracellular Matrix Destruction

JOURNAL ARTICLE published 23 February 2011 in Science Translational Medicine

Authors: Paul T. Elkington | Jeanine M. D’Armiento | Jon S. Friedland

Tobacco smoke exposure recruits inflammatory airspace monocytes that establish permissive lung niches for Mycobacterium tuberculosis

JOURNAL ARTICLE published 6 December 2023 in Science Translational Medicine

Authors: Björn Corleis | Constantine N. Tzouanas | Marc H. Wadsworth | Josalyn L. Cho | Alice H. Linder | Abigail E. Schiff | Björn Zessin | Fabian Stei | Anca Dorhoi | Amy K. Dickey | Benjamin D. Medoff | Alex K. Shalek | Douglas S. Kwon

An OX40/OX40L interaction directs successful immunity to hepatitis B virus

JOURNAL ARTICLE published 21 March 2018 in Science Translational Medicine

Research funded by National Institutes of Health (R01 DK093646) | National Institutes of Health (R56AI091872) | National Institutes of Health (P30DK026743) | National Institutes of Health (K01DK099405) | National Institutes of Health (K12GM081266) | National Institute of Diabetes and Digestive and Kidney Diseases (NIH F31 DK112607) | National Institutes of Health (T32AI007334-27)

Authors: Jean Publicover | Anuj Gaggar | Jillian M. Jespersen | Ugur Halac | Audra J. Johnson | Amanda Goodsell | Lia Avanesyan | Stephen L. Nishimura | Meghan Holdorf | Keith G. Mansfield | Joyce Bousquet Judge | Arya Koshti | Michael Croft | Adil E. Wakil | Philip Rosenthal | Eric Pai | Stewart Cooper | Jody L. Baron

Basic science: Stingy support stalls innovation

JOURNAL ARTICLE published 6 May 2015 in Science Translational Medicine

Authors: Kelly LaMarco

Elucidating the role of C9orf72 mutations in ALS

JOURNAL ARTICLE published 24 June 2015 in Science Translational Medicine

Authors: Jeffrey Statland

Science Translational Medicine Podcast: 24 June 2015

JOURNAL ARTICLE published 24 June 2015 in Science Translational Medicine

Authors: Nishant Agrawal | Annalisa VanHook

Screen time

JOURNAL ARTICLE published 24 June 2015 in Science Translational Medicine

Authors: Pamela Bhatti

Author response to comment on “Tracking donor-reactive T cells: Evidence for clonal deletion in tolerant kidney transplant patients”

JOURNAL ARTICLE published 22 July 2015 in Science Translational Medicine

Authors: Susan DeWolf | Heather Morris | Yufeng Shen | Megan Sykes

Clone wars

JOURNAL ARTICLE published 15 July 2015 in Science Translational Medicine

Authors: Grzegorz Nalepa

Add ARBs to injury?

JOURNAL ARTICLE published 22 July 2015 in Science Translational Medicine

Authors: Yo-El Ju

The curious case of intracranial lymphatics

JOURNAL ARTICLE published 12 August 2015 in Science Translational Medicine

Authors: Christopher G. Janson

MIF: A harbinger of evil

JOURNAL ARTICLE published 17 June 2015 in Science Translational Medicine

Authors: Gadi Lalazar

Fresh AIRE for autoimmune disease genetics

JOURNAL ARTICLE published 22 July 2015 in Science Translational Medicine

Authors: Alexander Marson

Comment on “Tracking donor-reactive T cells: Evidence for clonal deletion in tolerant kidney transplant patients”

JOURNAL ARTICLE published 22 July 2015 in Science Translational Medicine

Authors: Guy Gorochov | Martin Larsen | Christophe Parizot | Hélène Brisson | Mikalai Nienen | Leon Kuchenbecker | Nina Babel | Avidan U. Neumann